Study limitations included the single-center study design with a short observation period.Ĭitation: Ma X, Yang F, Wu J, Xu B, Jiang M, Sun Y, et al. No severe adverse events were observed in either group. PMR-AS, CRP, and ESR were all significantly decreased in both groups. At weeks 12 and 24, all patients in both groups had PMR-AS <10. There were no statistically significant differences in primary or secondary outcomes. Thirty-five patients (29 female, 6 male, age 64.4 ± 8.4) and 32 patients (23 female, 9 male, age 65.3 ± 8.7) patients completed the 24-week intervention, respectively. Thirty-nine patients with newly diagnosed PMR received tofacitinib, and 37 patients received glucocorticoid. Secondary endpoints: PMR-AS score, c-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) at weeks 12 and 24. The primary endpoint was the proportion of patients with PMR-AS ≤10 at weeks 12 and 24. All PMR patients underwent clinical and laboratory examinations at 0, 4, 8, 12, 16, 20, and 24 weeks, and PMR activity disease scores (PMR-AS) were calculated. In the second cohort, patients with PMR were randomized and treated with tofacitinib or glucocorticoids (1/1) for 24 weeks.

Furthermore, tofacitinib suppressed the IL-6R and JAK2 expression of CD4 +T cells from patients with PMR in vitro. We observed marked increases in expression of IL6R, IL1B, IL1R1, JAK2, TLR2, TLR4, TLR8, CCR1, CR1, S100A8, S100A12, and IL17RA, which could trigger JAK signaling. Inflammatory response and cytokine–cytokine receptor interaction were the most notable pathways affected. In the first cohort, we found that the gene expression patterns of peripheral blood mononuclear cells (PBMCs) in 11 patients (10 female, 1 male, age 68.0 ± 8.3) with newly diagnosed PMR were significantly different from 20 healthy controls (17 female, 3 male, age 63.7 ± 9.8) by RNA sequencing. We recruited treatment-naïve PMR patients from the First Affiliated Hospital, Zhejiang University School of Medicine, between September 2020 and September 2022.

Spss 16.0 free download for windows